Plasma aspirin hydrolysis variation
نویسندگان
چکیده
Background: Aspirin use is extensive, but its short half-life limits bioavailability. Results: Butyrylcholinesterase and PAFAH1b2 hydrolyze aspirin in plasma. Aspirin hydrolysis in plasma varies up to 12-fold from non-genetic modulation of butyrylcholinesterase activity. Conclusion: Two enzymes hydrolyze aspirin in plasma and their contribution varies among individuals. Significance: Aspirin hydrolysis in plasma is variable, affecting platelet inhibition by aspirin.
منابع مشابه
Dmd051805 1450..1456
The hydrolyzing properties of plasma esterases for aspirin were investigated in human plasma and plasma from experimental animals. The observed rates of aspirin hydrolysis were in the following order: rabbit > human > monkey > rat > mouse > dog > minipig. In human, monkey, and dog plasma, aspirin was hydrolyzed by their major hydrolases, paraoxonase (PON), butyrylcholinesterase (BChE), and albu...
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